Joel (Jim Carrey) and Clementine (Kate Winslet) are a couple trying to jump-start their romance by forgetting all the painful moments of their relationship with the help of a brand-new treatment that simply erases parts of their memories. But when Clementine has Joel erased from her memory, he wants her gone from his memory and asks the doctor (Tom Wilkinson) who invented the process for help. But as he recalls the remaining few memories of their time together, changes his mind, and tries to mentally overcome the procedure.